Intestinal Ischemia: Molecular Basis of Detection and Prevention

Abstract:

It is well known that the small bowel is particularly sensitive to ischemia and reperfusion injury. In situations such as mechanical occlusion, thromboembolism, sepsis, and low flow states, it is not uncommon to subject the small bowel to transient yet potentially reversible ischemia. Surgeons involved in the treatment of this entity are often faced with the dilemma - whether to cut or not, and to what extent should the tissue be resected proximal and distal to the ischemic injury.

Authors:

Umer M. Darr, M.D.; John P. Geibel, M.D., D.Sc. - Yale University School of Medicine, New Haven, Conn.

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