Ethicon

Ethicon

Novus Scientific

Abstract:

Although synthetic mesh has dramatically reduced recurrence in elective hernia repair, its use in contaminated surgical fields has been traditionally associated with complications such as wound sepsis, enterocutaneous fistulas, and chronic prosthetic infection. Biologic meshes emerged in the late 1990s with a rapid popularity fueled largely by the demand for an appropriate substitute in lieu of synthetic mesh in these complex cases; however, the high cost and rate of hernia recurrence have tempered the initial enthusiasm. Biosynthetic meshes were developed as a possible cost-effective alternative to both synthetic and tissue-derived products. Using biodegradable polymers instead of animal or cadaver tissue, they provide a temporary scaffold for deposition of proteins and cells necessary for tissue ingrowth, neovascularization, and host integration. Herein we review the current status of biosynthetic meshes for hernia repair.

Authors:

Mimi Kim, MD, FACS, Fellow, Minimally Invasive Surgery, Division of Gastrointestinal and Minimally Invasive Surgery, Bindhu Oommen, MD, MPH, Fellow, Minimally Invasive Surgery, Division of Gastrointestinal and Minimally Invasive Surgery, Samuel W. Ross, MD, MPH, Resident, General Surgery, Division of Gastrointestinal and Minimally Invasive Surgery, Amy E. Lincourt, PhD, MBA, Director of Research Division of Gastrointestinal and Minimally Invasive Surgery, Brent D. Matthews, MD, FACS, Professor of Surgery, Chairman, Department of Surgery, B. Todd Heniford, MD, FACS, Professor of Surgery, Chief, Division of Gastrointestinal and Minimally Invasive Surgery, Vedra A. Augenstein, MD, FACS, Clinical Assistant Professor of Surgery, Division of Gastrointestinal and Minimally Invasive Surgery, Department of Surgery, Carolinas Medical Center, Charlotte, North Carolina

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