Abstract:

Three isoforms of endothelin (ET) exist, ET-l, ET-2,and ET-3.Nucleotide sequences for the three human ET genes are highly conserved. ET-l exactly matches the sequence ofET originally isolated from the conditioned medium of cultured bovine aortic endothelial cells (BAECs). All three forms have been found in vascular, neural, adrenal, and kidney tissue, but are expressed in different proportions. Endothelial cells exclusively produce ET_1. All three isoforms have different vasoconstrictive potencies but are otherwise qualitatively similar. ET-2 is the most potent vasoconstrictor, followed by ET-l and ET_3.

Authors:

Jason T. Koo, M.D., Mark D. Sawyer, M.D., Richard J. Powell, M.D., Bauer E. Sumpio, M.D., Ph.D., F.A.C.S., Yale University School of Medicine, New Haven, CT

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