Abstract:

The main direction in modern imaging is increasing the spatial resolution and selectivity for pathology pattern recognition at the microscale. Dynamic optical imaging (DOl) has enormous potential in the selectivity of description of living tissue state at cellular and subcellular levels. However, multiple light scattering creates considerable difficulties in revealing the tissue microstructure in its depth. On the other hand, along with changes in the microstructure, pathology should also manifest itself in the integral macroscopic pattern of the tissue. Actually, living tissue, as a distributed active media with well-developed reception and self-regulation, is characterized by a high spatial synergy. In such a media, even morphologically small pathology could disturb tissue functioning in a rather extended area. As a result, after some definite time, a diffuse "field" of the pathological phenomena appears even in the morphological image. Since optical contrast is determined by tissue components (such as blood), which actively participate in physiological functioning, the distributed functional pattern of the tissue is reflected in optical images in the form of spatiotemporal modulation of the optical density. This observation opens up the possibility of investigating the diffuse pattern of the pathology at the functional stage of its development, even before the actual appearance of noticeable morphological changes.

Authors:

Edward Godik, Ph.D., Dynamics Imaging, Inc., Washington Township, NJ; Tamas Gergely, Applied Logic Laboratory, Budapest, Hungary; Vladimir Liger, Ph.D., Vladimir Zlatov, M.S., Dynamics Imaging, Inc., Washington Township, NJ; Alex Taratorin, Ph.D., Technion-Israel Institute of Technology, Haifa, Israel

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