Abstract:

The purpose of this study was to assess the use of a novel bone void filler consisting of Type I collagen and various growth factors (VEGF, TGFß-1, TGFß-2, IGF-1, BMP-2, BMP-3, and BMP-7) and surgical fixation to treat diaphyseal forearm pseudarthroses. Eleven patients underwent an osteosynthesis procedure for isolated pseudarthrosis fractures of the forearm (six radial and five ulnar diaphysis). The mean duration between the initial failed surgical fixation and re-operation was 38 weeks. Radiographic signs of fracture healing after the application of the bone void filler were noted at a mean of 5 weeks, and complete fracture consolidation was achieved at a mean of 6 weeks. All patients demonstrated improved range of motion and grip strength. Additionally, all patients were pain-free by 6 weeks. The combination of a novel bovine bone-derived bone void filler and stable internal fixation led to union and rapid healing of forearm pseudarthroses.

Authors:

M. Strassmair, M.D., Director, Division of Hand Surgery, Department of Orthopaedic Surgery, Klinikum Starnberg, Starnberg, Germany, M.A. Mont, M.D., Director, Center for Joint Preservation and , Reconstruction, Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, Baltimore, Maryland, USA, T.M. Seyler, M.D., Fellow, Center for Joint Preservation and , Reconstruction, Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, Baltimore, Maryland, USA, H. Bosebeck, Ph.D., Chief Scientist & Medical Affairs, Heraeus Medical, Wehrheim, Germany, D.R. Marker, B.S., Medical Student, Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine,, Baltimore, Maryland, USA, D.M. LaPorte, M.D., Assistant Professor, Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine,, Baltimore, Maryland, USA

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