Abstract:

Background: Optimized pulsed electrical stimulation (PES) regulates chondrocyte genes, enhances production of cartilage matrix materials, and inhibits production of matrix catabolic factors. Methods: This prospective, cohort study examined the use of a PES device in treatment of knee osteoarthritis (OA) in patients who had failed non-operative therapy. Primary outcome measures were patient and physician global evaluation, and patient assessment of knee pain.

Authors:

Jack Farr, M.D., Indiana University Medical Center, Indianapolis, IN; Michael A. Mont, M.D., Rubin Institute for Advanced Orthopedics, Baltimore, MD; Douglas Garland, M.D., University of Southern California, Long Beach, CA; Jacques R. Caldwell, M.D., Bionicare Medical Technologies, Inc., Sparks, MD; Thomas M. Zizic, M.D., Johns Hopkins University School of Medicine, Baltimore, MD, Bionicare Medical Technologies, Inc., Sparks, MD

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