Treatment of Articular Cartilage Defects With The Autologous Chondrocyte Transplantation (Act)

Abstract:

Symptomatic chondral lesions in the knee remain a problem for young sportsmen and pose a difficult management issue for or thopedic surgeons and patients alike. Damaged articular cartilage has a Iimited potential for healing and can lead to premature arthritis. Articular defects larger than 2 mm to 4 mm in diameter rarely heal. Neither articular cartilage possesses a lymphatic drainage, a sufficient blood supply, nor neural elements. Also, they are sheltered even from immunological recognition, because of the extracellular matrix surrounding the chondrocyte.

Authors:

Andreas Burkart, M.D., Andreas Balthasar Imhoff, M.D.

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